Department of Biotechnology, Ministry of Science and Technology

Block-2, CGO Complex
Lodhi Road
New Delhi – 110003

Theme: Basic Research and Development of New Production Process and Devices using Nanoscience and Nanotechnology derived knowledge-based multifunctional materials for use in Agriculture, Medicine, Food Processing industry and Environment Management and their Toxicological Studies.

Nobel Prize in 1986 was awarded to Gerd Binning from Germany and Heinrich Roher from Switzerland, for discovering the first Scanning Tunnel microscope of STM. This invention realized the dream of prof. Richard Feymann (Nobel Prize winner, Physics, 1965). Therefore, nanoscience and nanotechnologies made their first tentative appearance two decades ago. Soon it was realized by the researchers that physics and chemistry of life and smaller that the width of a human hair) are not only novel but also excitingly new. The wonderful reunion has set the seal on a surprising rapprochement between fundamental research – working at the frontiers of the exploration of matter – and practical applications in a field, which is growing all the time. Nanoscience has changed radically the way in which scientist – physicists, chemists and biologists – have studied the atomic molecular world. Both ‘top down’ and ‘bottom-up’ approaches are adapted to artificially’ created molecular nanosystems with very specific properties. Therefore, nanoscience posses a fundamentally new scientific challenge as it requires a command or interactions between atoms. What is more, such interactions are not governed by the principles of traditional physics but by the complex laws of quantum mechanics.

• BT has set forth following of Nanoscience and Nanotechnology keeping in view of the present National priorities and future needs of our country.

  • Basic research on nanoscience, nonotechnology and nanometerial with future scope of application in biology, medicine, drugs, food, nutrition and alleviation of poverty.

    • Nanoscience and nanotechnology for improving soldiers’ and emergency relief workers’ lives, health, food and nutrition.

      • Biochip development

        • Diagnostics and therapeutic tools.

          • Micro nano technologies

            • Applications in health, agriculture, food, environment and industry Nano – technologies

              • Nano-biotechnology related to genomics, proteomics

                • Toxicological Studies of materials developed.

                These broad areas could be further categorized as:

                Enhancing the production and survival of soldiers and emergency relief worker’s life using nanoscience and nanotechnology; the detection, threat neutralization (such as bullet-proof and tsunami proof clothing), concealment enhanced human performance, real-time automated medical treatment and reduced logistical footprint (i.e. lightening the considerable weight load of the fully equipped soldier), design light weight food packaging material and food poison detection systems. Nano materials for guided bone regeneration or for wound healing based biocompatible and biogradable polymers, modification and optimization of implant surfaces, investigation of the influence of cell biology and growth behaviour by micro structuring of implant surfaces, preparation and characterization composite coatings from nano-hydroxyl apatite collagen on titanium implants oxidized anodically; Developing of new and effective protein-based nano-products in the area of local tissue regeneration, with the primary focus on bone and cartilage repair; nanoscaled immunotherapeutics, genetically engineered self-assembly systems, nanoarray coated virus like particles, functional protein arrays, Biomimetic membranes, nanocapsules and glycosylated nanorrays, Nano-dimensional bioactive polymer systems, for controlled drug release.

                Nano in tracer and bioanalysis, protein via nano-coupling methods, and clinical diagnosis of extremely small sample volumes for future human research, high-resolution imaging and bio-sensoring of proteins and membranes on the single molecule level, Nanoscale reactive chip and biosensor surfaces, functional hydrogels, hyper branched architectures and photosensitive polymers, Polymer matrices on gold-coated chips (nanofilms or self-assembled layers) and gold particles in porous materials as fluorescence enhancers, Imaging, neurons on a chip, functional surfaces etc.

                Nanoscale systems for studies of gene expression, stress regulation and signal transduction, investigations of structure-function relationships in proteins, protein engineering, development of biosensors for different processes, and studies of organelle biogenesis.

                Development of nanoscale system bases DNA microarray to follow up the gene expression, in adipose tissue in murine models of diseases, Development of biochips for the GMD detection, Microarray to monitor gene expression in breast tumours. Side effects detection of drug candidate on microrray, controlled synthesis of short DNA chain on metallic nanostructures with Structure plasmon resonance (SPR)

                Development of nanoscale system based biochips for the identification of pathogenic bacteria in food Development of biochip for the identification of nosocomian Pneumonia, Development of a biochip for the selection of disease resistant animals for veterinary, poultry and fisheries industry, Nanoparticles applicable in medicine, and ecology, Nanoparticles for applications in foodstuffs and food ingredients, nutraceuticalls, diagnostics, biosensors, enzyme catalysts, etc.

                Controlled metalization of protein made nanostructures, Enzyme-binding proteins for functional nanostructures. Self-assembly of protein ‘building-blocks’ to be used in self assembled nano-structures.

                Concepts papers (Maximum: 10 pages; single space typed in A4 size; Verdana style: 10 point from size) including a brief bio-data of PI and all Co-Pls demonstrating experience and expertise in the proposed area and proposed budget (see Annexure, which is available on website: www.dbtindia.nic.in ), may be submitted positively by 30th March, 2007 by post to: Dr.R.R.Sinha, Adviser, Department of Biotechnology, Block –2, 6th Floor, CGO Complex, Lodhi Road, New Delhi – 110003 and also by email: rrsinhadbt@gmail.com mentioning “Knowledge based Nanoscience Nanotechnology” in the subject area. Scientists who submitted their proposal in response to DBT’s earlier advertisement need to apply again

                Department of Biotechnology, Ministry of Science and Technology

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                Department Biotechnology Ministry Science Technology |  Nanoscience |  Nanotechnology |  Diagnostics therapeutic Micro nano